New Introducing Synthara-1 — therapeutic proteins from a single natural language prompt Read more →
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Erythrocruorin · PDB 2GTL · 180 subunits · D6 symmetry
Synthara-1 · Private beta

Generating
better molecules
from language

Describe any therapeutic target.
Synthara-1 designs the molecule.

Prompt
⌘ Enter
Design a GPCR antagonist for chronic pain Anti-VEGF for macular degeneration IL-6 blocker for sepsis PD-1 inhibitor for solid tumors Tie2 agonist · vascular stabilization
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Synthara-1 Model

A new foundation
for protein design

Synthara-1 is a single end-to-end generative model that accepts plain-language descriptions and outputs validated therapeutic proteins — sequence, 3D structure, and binding scores — in under a second.

Trained on 200 million protein structures and paired with a curated library of therapeutic targets, Synthara-1 understands biology through mechanism, function, and disease context.

Read the technical report →

Architecture · Synthara-1 end-to-end model

Biomedical Language Encoder
Semantic grounding · target comprehension
Joint Sequence + Structure Diffusion
3D-aware · latent protein manifold
Therapeutic Alignment Layer
Druggability · safety · immunogenicity
Confidence Scoring
pLDDT · i_PAE · ΔΔG · RMSD
Therapeutic candidate · ready for wet lab validation
95%
Average pLDDT
structural confidence
<1s
Generation time
per candidate
200M+
Protein structures
in training corpus
40+
Therapeutic target
classes supported

Research Applications

Where Synthara
changes outcomes

From oncology to rare vascular disease — built for the hardest targets in medicine.

01

Oncology &
Immuno-oncology

Design checkpoint inhibitors, bispecifics, and tumor-targeting antibodies with specificity constraints embedded directly in your prompt.

PD-1CTLA-4HER2EGFR

02

Vascular &
Angiogenesis

Generate Tie2-activating antibodies, anti-VEGF candidates, and angiopoietin axis modulators for cancer, retinopathy, and sepsis.

Tie2VEGFAng-1eNOS

03

Inflammation &
Autoimmune

Rapidly iterate cytokine blockers and receptor antagonists for IBD, rheumatoid arthritis, and inflammatory disease.

IL-6TNFαJAKIL-17

Describe the disease.
We design the molecule.

Join leading research teams using Synthara-1 to accelerate therapeutic discovery.